Charles C. Hsu, MD, PhD

Charles C. Hsu, MD, PhD

Associate Professor

Contact Information

Office Location: 
3838 N Campbell Ave., BLDG 2
Phone Number: 


Dr. Hsu serves as an Associate Professor of Radiation Oncology at the University of Arizona College of Medicine.  His clinical and research interests focus on thoracic and cutaneous malignancies, stereotactic body radiotherapy and HDR brachytherapy. 

Dr. Hsu received his Bachelor’s Degree with high honors from Princeton University followed by a Fulbright Fellowship pursuing hepatitis research.  Dr. Hsu earned his medical degree and doctorate in epidemiology from the Johns Hopkins Schools of Medicine and Public Health in Baltimore, MD and also completed a post-doctoral fellowship in cancer epidemiology with the World Health Organization in Lyon, France.  He completed his internship at Memorial Sloan-Kettering Cancer Center in New York followed by residency at the University of California-San Francisco, where he also served as Chief Resident. 

Professional Affiliations: 

American Society of Radiation Oncology (ASTRO)

American Brachytherapy Society (ABS)

American College of Radiation Oncology (ACRO)


2002    Robert Dyar Memorial Award for Epidemiology and Medicine

2002    Hoobler Award for Excellence in Public Health and Medicine

2003    National Kidney Foundation of Maryland Mini-Grant

2003    American Diabetes Association Medical Scholars Award

2004    World Health Organization IARC Training Fellowship

2005    American Society of Preventive Oncology New Investigator Travel Grant

2008    Sino-American Network for Therapeutic Radiology and Oncology

Resident/Junior Investigator Award

2010    Cancer of the Prostate Strategic Urologic Research Endeavor Scholar

2011    UCSF Resident Research Travel Award

2012    UCSF Chief Resident

2013    American Brachytherapy Society HDR Brachytherapy Fellowship

2015    Visiting Professor, National Taiwan University Department of Radiation Oncology, Taipei, Taiwan

2015     Visiting Professor, Taipei Veterans General Hospital, Department of Radiation Oncology, Taipei, Taiwan


Board Certifications: 

American Board of Radiology


World Health Organization-International Agency for Research on Cancer
University of California at San Francisco
Medical School: 
The Johns Hopkins School of Medicine
Master's Degree: 
The Johns Hopkins School of Public Health
Undergraduate School: 
Princeton University


Selected Publications: 

Shiraishi Y, Fang P, Xu C, Song J, Krishnan S, Koay EJ, Mehran RJ, Hofstetter WL, Blum-Murphy M, Ajani JA, Komaki R, Minsky B, Mohan R, Hsu CC, Hobbs BP, Lin SH.  Severe lymphopenia during neoadjuvant chemoradiation for esophageal cancer: A propensity matched analysis of the relative risk of proton versus photon-based radiation therapy.  Radiother Oncol. 2017 Dec 13. pii: S0167-8140(17)32751-2.

Davuluri R, Jiang W, Fang P, Xu C, Komaki R, Gomez DR, Welsh J, Cox JD, Crane CH, Hsu CC, Lin SH.  Lymphocyte Nadir and Esophageal Cancer Survival Outcomes After Chemoradiation Therapy.  Int J Radiat Oncol Biol Phys. 2017 Sep 1;99(1):128-135. doi: 10.1016/j.ijrobp.2017.05.037. Epub 2017 Jun 1.

Likhacheva AO, Devlin PM, Shirvani SM, Barker CA, Beron P, Bhatnagar A, Doggett SW, Hochman L, Hsu CC, Kasper M, Keisch M, Mutyala S, Prestidge B, Rodriguez Villalba S, Shukla V, Sundararaman S, Kamrava M.  Skin surface brachytherapy: A survey of contemporary practice patterns.  Brachytherapy. 2017 Jan - Feb;16(1):223-229. doi: 10.1016/j.brachy.2016.10.006. Epub 2016 Nov 28.

Rao AD, Liu Y, von Eyben R, Hsu CC, Hu C, Rosati LM, Parekh A, Ng K, Hacker-Prietz A, Zheng L, Pawlik TM, Laheru DA, Jaffee EM, Weiss MJ, Le DT, Hruban RH, De Jesus-Acosta A, Wolfgang CL, Narang AK, Chang DT, Koong AC, Herman JM.  Multiplex Proximity Ligation Assay to Identify Potential Prognostic Biomarkers for Improved Survival in Locally Advanced Pancreatic Cancer Patients Treated With Stereotactic Body Radiation Therapy.  Int J Radiat Oncol Biol Phys. 2018 Feb 1;100(2):486-489. doi: 10.1016/j.ijrobp.2017.10.001. Epub 2017 Oct 12.

Jones KM, Stuehm CA, Hsu CC, Kuo PH, Pagel MD, Randtke EA. Imaging Lung Cancer by Using Chemical Exchange Saturation Transfer MRI With Retrospective Respiration Gating. Tomography. 2017 Dec;3(4):201-210. doi: 10.18383/j.tom.2017.00017.

Penny Fang, Wen Jiang, MD, PhD; Rajayogesh Davuluri, MD; Cai  Xu, MD; Sunil  Krishnan, MD; Radhe Mohan, PhD; Albert C Koong, MD, PhD; Charles C Hsu, MD, PhD; Steven  H Lin, MD, PhD.  High Lymphocyte Count during Neoadjuvant Chemoradiotherapy is Associated with Improved Pathologic Complete Response in Esophageal Cancer.   Radiotherapy and Oncology 2018. 

Stea B, Skrepnik T, Hsu CC, Abendroth R.  The role of radiation therapy in the treatment of metastatic cancer. Clin Exp Metastasis. 2018 Jul 30. doi: 10.1007/s10585-018-9926-6. 

Herman JM, Jabbour SK, Lin SH, Deek MP, Hsu CC, Fishman EK, Kim S, Cameron JL, Chekmareva M, Laheru DA, Narang AK, Pawlik TM, Hruban RH, Wolfgang CL, Iacobuzio-Donahue CA. Smad4 Loss Correlates With Higher Rates of Local and Distant Failure in Pancreatic Adenocarcinoma Patients Receiving Adjuvant Chemoradiation.  Pancreas. 2018 Feb;47(2):208-212. doi: 10.1097/MPA.0000000000000985.

Eshghi N, Garland L, Choudhary G, Hsu CC, Eshghi A, Han J, Hamilton RJ, Krupinski E, Kuo PH.   Pilot Study: Regional Changes in Brain 18F-FDG Uptake After Prophylactic Cranial Irradiation and Chemotherapy in small cell lung cancer May Reflect Functional Changes. J Nucl Med Technol. 2018 Aug 3. pii: jnmt.118.212316. doi: 10.2967/jnmt.118.212316. 

Samuel S. Kim, Zain Khalpey, Charles Hsu, Alex G. Little. Changes in Tracheostomy- and Intubation-Related Tracheal Stenosis: Implications for Surgery The Annals of Thoracic Surgery, Volume 104, Issue 3, September 2017, Pages 964-970

Clinical Studies

Titlesort descending Description Cancer Area Cancer Type Trial Status
ANAM 17-21 Cachexia

NCT03743064 A Phase 3, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of anamorelin HCl for the treatment of malignancy associated weight loss and anorexia in adult patients with advanced non-small cell lung cancer (NSCLC).

Astrazeneca/ Pacifica 4

NCT03833154 A Phase III, Randomised, Double-blind, Placebo-controlled, Multi-centre, International Study of Durvalumab following stereotactic body radiation therapy (SBRT) for the treatment of Patients with Stage I/II Non Small Cell Lung Cancer


NCT03712605 A Phase III Randomized Trial Comparing Adjuvant MK-3475 (Pembrolizumab) to Standard of Care Observation in Completely Resected Merkel Cell Carcinoma


NCT03811002 Limited Stage Small Cell Lung Cancer (LS-SCLC): A Phase II/III Randomized Study of Chemoradiation versus Chemoradiation Plus Atezolizumab


NCT03137771: Maintenance Systemic Therapy Versus Consolidative Stereotactic Body Radiation Therapy (SBRT) Plus Maintenance Systemic Therapy for Limited Metastatic Non-Small Cell Lung Cancer (NSCLC): A Randomized Phase II/III Trial


NCT04155034 MRI Brain Surveillance Alone Versus MRI Surveillance and Prophylactic Cranial Irradiation (PCI): A Randomized Phase III Trial in Small-Cell Lung Cancer (MAVERICK)